Use a retinoid - Retinoids, which are derived from vitamin ATrusted Source, are one of the most studied anti-aging ingredients. Sometimes referred to as retinol, retinoids have the ability to increase collagen production, which helps plumps up the skin. Retinoids also encourage skin regeneration and can promote the creation of new blood vessels, which may help improve the skin’s overall appearance and texture. There are five main types of retinoids, each with slightly different degrees of potency. Some are available in creams and gels that you can buy over the counter, while others are available by prescription only.